⭐⭐⭐⭐⭐ History Of Anesthetics

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History Of Anesthetics



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With an eye toward making further advances in this new science as well as offering treatment for diseases previously thought to be untreatable such as asthma and tuberculosis , Beddoes founded the Pneumatic Institution for inhalation gas therapy in at Dowry Square in Clifton, Bristol. Other members of the Lunar Society such as Erasmus Darwin and Josiah Wedgwood were also actively involved with the institute. During the course of his research at the Pneumatic Institution, Davy discovered the anesthetic properties of nitrous oxide. Davy was not a physician, and he never administered nitrous oxide during a surgical procedure.

He was, however, the first to document the analgesic effects of nitrous oxide, as well as its potential benefits in relieving pain during surgery: [49]. Beginning in about , Hanaoka embarked on a quest to re-create a compound that would have pharmacologic properties similar to Hua Tuo's mafeisan. Like that of Hua Tuo, this compound was composed of extracts of several different plants, including: [52] [53] [54].

Although the original manuscript was lost in a fire in , this brochure described the current state of Hanaoka's research on general anesthesia. This is generally regarded today as the first reliable documentation of an operation to be performed under general anesthesia. Before his death in , Hanaoka performed more than operations for breast cancer. Henry Hill Hickman — experimented with the use of carbon dioxide as an anesthetic in the s. He would make the animal insensible, effectively via almost suffocating it with carbon dioxide, then determine the effects of the gas by amputating one of its limbs.

In , Hickman submitted the results of his research to the Royal Society in a short treatise titled Letter on suspended animation: with the view of ascertaining its probable utility in surgical operations on human subjects. The response was an article in The Lancet titled "Surgical Humbug" that ruthlessly criticised his work. Hickman died four years later at age Though he was unappreciated at the time of his death, his work has since been positively reappraised and he is now recognised as one of the fathers of anesthesia.

By the late s, Humphry Davy's experiments had become widely publicized within academic circles in the northeastern United States. Wandering lecturers would hold public gatherings, referred to as "ether frolics", where members of the audience were encouraged to inhale diethyl ether or nitrous oxide to demonstrate the mind-altering properties of these agents while providing much entertainment to onlookers. Long — , Horace Wells — , and William T. Morton — While attending undergraduate school in Rochester, New York, in , classmates Clarke and Morton apparently participated in ether frolics with some regularity. Clarke apparently thought little of his accomplishment, and chose neither to publish nor to pursue this technique any further.

Indeed, this event is not even mentioned in Clarke's biography. Crawford W. Long was a physician and pharmacist practicing in Jefferson, Georgia in the midth century. During his time as a student at the University of Pennsylvania School of Medicine in the late s, he had observed and probably participated in the ether frolics that had become popular at that time. At these gatherings, Long observed that some participants experienced bumps and bruises, but afterward had no recall of what had happened. He postulated that diethyl ether produced pharmacologic effects similar to those of nitrous oxide. On 30 March , he administered diethyl ether by inhalation to a man named James Venable, in order to remove a tumor from the man's neck.

He went on to employ ether as a general anesthetic for limb amputations and parturition. Long, however, did not publish his experience until , thereby denying himself much of the credit he deserved. With the beginnings of modern medicine the stage was set for physicians and surgeons to build a paradigm in which anesthesia became useful. One of the participants, Samuel A. Cooley , sustained a significant injury to his leg while under the influence of nitrous oxide without noticing the injury. Horace Wells, a Connecticut dentist present in the audience that day, immediately seized upon the significance of this apparent analgesic effect of nitrous oxide.

The following day, Wells underwent a painless dental extraction while under the influence of nitrous oxide administered by Colton. Wells then began to administer nitrous oxide to his patients, successfully performing several dental extractions over the next couple of weeks. William T. Morton, another New England dentist, was a former student and then-current business partner of Wells. He was also a former acquaintance and classmate of William Edward Clarke the two had attended undergraduate school together in Rochester, New York. Morton arranged for Wells to demonstrate his technique for dental extraction under nitrous oxide general anesthesia at Massachusetts General Hospital , in conjunction with the prominent surgeon John Collins Warren.

This demonstration, which took place on 20 January , ended in failure when the patient cried out in pain in the middle of the operation. On 30 September , Morton administered diethyl ether to Eben Frost, a music teacher from Boston , for a dental extraction. Two weeks later, Morton became the first to publicly demonstrate the use of diethyl ether as a general anesthetic at Massachusetts General Hospital, in what is known today as the Ether Dome.

Upon completion of the procedure, Warren reportedly quipped, "Gentlemen, this is no humbug. Morton published his experience soon after. Long later petitioned William Crosby Dawson — , a United States Senator from Georgia at that time, to support his claim on the floor of the United States Senate as the first to use ether anesthesia. In , Scottish obstetrician James Young Simpson — of Edinburgh was the first to use chloroform as a general anesthetic on a human Robert Mortimer Glover had written on this possibility in but only used it on dogs.

The use of chloroform anesthesia expanded rapidly thereafter in Europe. Chloroform began to replace ether as an anesthetic in the United States at the beginning of the 20th century. It was soon abandoned in favor of ether when its hepatic and cardiac toxicity , especially its tendency to cause potentially fatal cardiac dysrhythmias , became apparent. In fact, the use of chloroform versus ether as the primary anesthetic gas varied by country and region.

For instance, Britain and the American South stuck with chloroform while the American North returned to ether. Through his careful clinical records he was eventually able to convince the elite of London medicine that anesthesia chloroform had a rightful place in childbirth. Thus, in Queen Victoria's accoucheurs invited John Snow to anesthetize the Queen for the birth of her eighth child. A mask was placed over the patient's mouth with some fabric in it and the volatile liquid was dropped onto the mask with the patient spontaneously breathing.

Later development of safe endotracheal tubes changed this. After Austrian diplomat Karl von Scherzer brought back sufficient quantities of coca leaves from Peru, in Albert Niemann isolated cocaine, which thus became the first local anesthetic. In , the German surgeon Friedrich Trendelenburg — published a paper describing the first successful elective human tracheotomy to be performed for the purpose of administration of general anesthesia.

In , the Scottish surgeon William Macewen — reported on his use of orotracheal intubation as an alternative to tracheotomy to allow a patient with glottic edema to breathe, as well as in the setting of general anesthesia with chloroform. Kirstein performed the first direct laryngoscopy in Berlin, using an esophagoscope he had modified for this purpose; he called this device an autoscope. The 20th century saw the transformation of the practices of tracheotomy, endoscopy and non-surgical tracheal intubation from rarely employed procedures to essential components of the practices of anesthesia, critical care medicine , emergency medicine , gastroenterology , pulmonology and surgery.

In , Hermann Emil Fischer — and Joseph von Mering — discovered that diethylbarbituric acid was an effective hypnotic agent. Until , oral and maxillofacial surgery was performed by mask inhalation anesthesia , topical application of local anesthetics to the mucosa , rectal anesthesia, or intravenous anesthesia. While otherwise effective, these techniques did not protect the airway from obstruction and also exposed patients to the risk of pulmonary aspiration of blood and mucus into the tracheobronchial tree. In , Chevalier Jackson — was the first to report a high rate of success for the use of direct laryngoscopy as a means to intubate the trachea.

Also in , Henry H. Janeway — published results he had achieved using a laryngoscope he had recently developed. With this in mind, he developed a laryngoscope designed for the sole purpose of tracheal intubation. Similar to Jackson's device, Janeway's instrument incorporated a distal light source. Unique, however, was the inclusion of batteries within the handle, a central notch in the blade for maintaining the tracheal tube in the midline of the oropharynx during intubation and a slight curve to the distal tip of the blade to help guide the tube through the glottis. The success of this design led to its subsequent use in other types of surgery. Janeway was thus instrumental in popularizing the widespread use of direct laryngoscopy and tracheal intubation in the practice of anesthesiology.

In Arthur Ernest Guedel introduced the cuffed endotracheal tube, which allowed deep enough anesthesia that completely suppressed spontaneously respirations while the gas and oxygen were delivered via positive pressure ventilation controlled by the anesthesiologist. Only three years later Joseph W. Gale developed the technology where the anesthesiologist was able to ventilate only one lung at a time. Eventually by early s double lumen endotracheal tubes made out of clear plastic enabled anesthesiologists to selectively ventilate one lung while using flexible fiberoptic bronchoscopy to block off the diseased lung and prevent cross contamination. Lucien E. Morris at the University of Wisconsin.

Sodium thiopental , the first intravenous anesthetic , was synthesized in by Ernest H. Volwiler — and Donalee L. Tabern — , working for Abbott Laboratories. Waters in an investigation of its properties, which were short-term anesthesia and surprisingly little analgesia. Volwiler and Tabern were awarded U. Patent No. In , the search for a synthetic substitute for atropine culminated serendipitously in the discovery of meperidine, the first opiate with a structure altogether different from that of morphine.

After World War I , further advances were made in the field of intratracheal anesthesia. Among these were those made by Sir Ivan Whiteside Magill — Stanley Rowbotham — , Magill developed the technique of awake blind nasotracheal intubation. The first hospital anesthesia department was established at the Massachusetts General Hospital in , under the leadership of Henry K. Beecher — Beecher, who received his training in surgery, had no previous experience in anesthesia. Although initially used to reduce the sequellae of spasticity associated with electro-shock therapy for psychiatric disease, curare found use in the operating rooms at Bellvue by E.

Papper and Stuart Cullen in the s using preparations made by Squibb. At first anesthesiologists hesitated to bring the ventilator into the operating theater unless necessary, but by the s it became standard operating room equipment. Sir Robert Macintosh — achieved significant advances in techniques for tracheal intubation when he introduced his new curved laryngoscope blade in Hex Venn who was at that time the anesthetic advisor to the British firm Eschmann Bros. Venn's design was accepted in March , and what became known as the Eschmann endotracheal tube introducer went into production later that year.

This provided more stiffness but maintained the flexibility and the slippery surface. For over a hundred years the mainstay of inhalational anesthetics remained ether with cyclopropane , which had been introduced in the s. In halothane [] was introduced which had the significant advantage of not being flammable. This reduced the risk of operating room fires. In the sixties the halogenated ethers superseded Halothane due to the rare, but significant side effects of cardiac arrhythmias and liver toxicity. The first two halogenated ethers were methoxyflurane and enflurane.

These in turn were replaced by the current standards of isoflurane , sevoflurane , and desflurane in the eighties and nineties although methoxyflurane remains in use for prehospital anesthesia in Australia as Penthrox. Halothane remains in common place throughout much of the developing world. Many new intravenous and inhalational anesthetics were developed and brought into clinical use during the second half of the 20th century. Paul Janssen — , the founder of Janssen Pharmaceutica , is credited with the development of over 80 pharmaceutical compounds.

The concept of using a fiberoptic endoscope for tracheal intubation was introduced by Peter Murphy , an English anesthetist, in The "digital revolution" of the 21st century has brought newer technology to the art and science of tracheal intubation. Several manufacturers have developed video laryngoscopes which employ digital technology such as the complementary metal—oxide semiconductor active pixel sensor CMOS APS to generate a view of the glottis so that the trachea may be intubated. The Glidescope video laryngoscope is one example of such a device. Xenon has recently been approved in some jurisdictions as an anaesthetic agent which does not act as a greenhouse gas.

From Wikipedia, the free encyclopedia. This section needs expansion. You can help by adding to it. February After watching his colleague Horace Wells unsuccessfully promote nitrous oxide as an anesthetic, Morton concentrated on the possibility of ether. Also called trichloromethane, chloroform is prepared through the chlorination of methane gas. It was first prepared in by the American chemist Dr. Samuel Guthrie, who combined whiskey with chlorinated lime in an attempt to produce a cheap pesticide. In , the Scottish physician Sir James Young Simpson first used the sweet-smelling, colorless, non-flammable liquid as an anesthetic.

When administered by dripping the liquid onto a sponge or cloth held so that the patient inhaled the vapors, chloroform was seen to have narcotic effects on the central nervous system, and produced these effects relatively quickly. On the other hand, there were higher risks associated with chloroform than with ether, and its administration required greater physician skill. There were early reports of fatalities due to chloroform, beginning with a year-old girl in Skill and care were required to differentiate between an effective dose enough to make patient insensible during surgery and one that paralyzed the lungs, causing death. Fatalities were widely publicized, and the risks involved led some patients facing surgery to decline anesthesia and brave the pain.

American military doctors began using ether as an anesthetic on the battlefield during the Mexican-American War , and by it was officially issued by the U. Though many army doctors and nurses had experience with using ether by the time of the Civil War , chloroform became more popular during that conflict, due to its faster-acting nature and a large number of positive reports of its usage during the Crimean War in the s. During the Civil War, chloroform was used whenever it was available to reduce the pain and trauma of amputation or other procedures. Usage of ether and chloroform later declined after the development of safer, more effective inhalation anesthetics, and they are no longer used in surgery today.

Chloroform in particular came under attack in the 20th century, and was shown to be carcinogenic by ingestion in laboratory mice and rats. It is now used mainly in the preparation of fluorocarbons, used in aerosol propellants and refrigerants; it is also found in some cough and cold medicines, dental products including toothpaste and mouthwashes , topical liniments and other products. But if you see something that doesn't look right, click here to contact us! Subscribe for fascinating stories connecting the past to the present. A young Boston Dentist, Dr. Morton had been in the search for a better agent than what had been used by many dentists: nitrous oxide.

With Dr. Morton's tenacity driven by enthusiasm and discovery, he and renowned surgeon at Massachusetts General Hospital, John Collins Warren made history on October 16, with the first successful surgical procedure performed with anesthesia. Morton had single-handedly proven to the world that ether is a gas that when inhaled in the proper dose, provided safe and effective anesthesia. One of the first accounts of an endotracheal tube being used for an airway comes from the pediatrician Joseph O'Dwyer He used the metal "O'dwyer" tubes in diphtheria cases and passed them into the trachea blindly. Adding a cuff to the tube is credited to Arthur Guedel and Ralph M.

Waters in

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